In vitro platforms for evaluating liver toxicity
نویسندگان
چکیده
منابع مشابه
In vitro models for liver toxicity testing.
Over the years, various liver-derived in vitro model systems have been developed to enable investigation of the potential adverse effects of chemicals and drugs. Liver tissue slices, isolated microsomes, perfused liver, immortalized cell lines, and primary hepatocytes have been used extensively. Immortalized cell lines and primary isolated liver cells are currently most widely used in vitro mod...
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Toxicogenomics (TGx) is a widely used technique in the preclinical stage of drug development to investigate the molecular mechanisms of toxicity. A number of candidate TGx biomarkers have now been identified and are utilized for both assessing and predicting toxicities. Further accumulation of novel TGx biomarkers will lead to more efficient, appropriate and cost effective drug risk assessment,...
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ژورنال
عنوان ژورنال: Experimental Biology and Medicine
سال: 2014
ISSN: 1535-3702,1535-3699
DOI: 10.1177/1535370214531872